THE PETPACE COLLAR IN ACTION- TREATING HEART DISEASE IN THE HOSPITAL AND BEYOND

 Patient Condition and History

Chester, a 10-year-old, 43lb, male American Cocker Spaniel, was presented to MediVet Warbreck House Veterinary Centre in Liverpool, UK, after suffering from weakness, lethargy and labored breathing for 24 hours. Chester’s medical history included Chronic Kidney Disease (IRIS stage 2), Hypothyroidism, Hypertension, Anterior Cruciate Repair, and recurrent Otitis (ear infections). He has received long-term medication for these conditions.

On physical exam, Dr. Andrew McVey, Chester’s veterinarian, detected increased respiratory rate with inspiratory effort. Bloodwork showed moderate but stable azotemia (compatible with his Chronic Kidney Disease). Chest radiographs revealed pulmonary edema with marked cardiomegaly. An echocardiogram followed and showed significant left side dilation and decreased fractional shortening. The clinical diagnosis was DCM with secondary CHF.

Dilated Cardiomyopathy, or DCM, is a disease of the heart muscle characterized by enlargement of heart chambers. It involves decreased contractility of the heart muscle and subsequent enlargement to compensate for the decreased functionality. DCM may eventually lead to Congestive Heart Failure (CHF), where fluids accumulate in the patient’s lungs, abdomen, and more.

Chester was hospitalized and received intravenous Pimobendan, a drug intended to increase the contractile force of the heart. He also received supportive care and close monitoring. Diuretics were not used because of his pre-existing azotemia. A PetPace collar was placed on Chester to help closely monitor his condition during hospitalization and at home, following his release.

Monitoring Data

Chester was sent home with the PetPace collar to continuously monitor his recovery, and he now wears the collar constantly. His pulse indices showed a clear improvement immediately after starting treatment with Pimobendan (initially intravenously and later orally). Likewise, Chester’s Heart Rate Variability (HRV) improved significantly after the first day. These improvements serve as a clinical indicator of the positive effect of the medications.

Chart, line chart

Description automatically generated* Chester’s aggregated pulse data during the first 2 days, showing overall decreased pulse rate (indicating better cardiac performance) on the second day compared to the first.

* CHESTER’S AGGREGATED PULSE DATA DURING THE FIRST 2 DAYS, SHOWING OVERALL DECREASED PULSE RATE (INDICATING BETTER CARDIAC PERFORMANCE) ON THE SECOND DAY COMPARED TO THE FIRST.

* Daily average, maximum and minimum pulse rates showing clear improvements on days 2 and 3 following introduction of Pimobendan.

* DAILY AVERAGE, MAXIMUM AND MINIMUM PULSE RATES SHOWING CLEAR IMPROVEMENTS ON DAYS 2 AND 3 FOLLOWING INTRODUCTION OF PIMOBENDAN.

Chart, line chart

Description automatically generated* Daily HRV (VVTI) shows significant improvement after the first day following treatment

* DAILY HRV (VVTI) SHOWS SIGNIFICANT IMPROVEMENT AFTER THE FIRST DAY FOLLOWING TREATMENT

As shown in the more recent graphs below, several weeks after his hospitalization, Chester’s pulse and respiration rates – closely monitored by his PetPace collar – were still slightly higher than normal, but stable. HRV and activity values were stable as well. Repeated examinations at the hospital confirmed that Chester had recovered from the CHF, and was doing well, but that he will need to take his medications on a regular basis.

* Daily average pulse and respiratory rates were slightly higher than normal but stable

* DAILY AVERAGE PULSE AND RESPIRATORY RATES WERE SLIGHTLY HIGHER THAN NORMAL BUT STABLE

* Daily activity and HRV (Triangular Index) showing stable values at home

* DAILY ACTIVITY SHOWING STABLE VALUES AT HOME

Chart, line chart

Description automatically generated* Daily HRV (Triangular Index) showing stable values at home

* DAILY HRV (TRIANGULAR INDEX) SHOWING STABLE VALUES AT HOME

Discussion

The American Cocker Spaniel breed has a predilection to DCM. There is no cure for this disease, but it seems possible to maintain it at stable or asymptomatic levels for several years. However, these dogs are always at risk of developing severe, life-threatening complications like Heart Failure or lethal arrhythmias. Monitoring pulse rate, HRV, and other relevant parameters is therefore of high value in managing patients with DCM.

The PetPace collar provides accurate real-time and long-term trends data that helps caregivers adjust treatment plans for optimal clinical results in DCM patients.

Conclusions

The PetPace collar can accurately detect short- and long-term changes in key parameters that help caregivers manage DCM. Clinicians can use data accrued to assess the condition’s severity, measure the patient’s response to treatment, and enable timely detection of deterioration. The preliminary phases of the disease, which typically develop over several years before symptoms manifest, may be detectable via certain changes in trends data – allowing early detection and intervention.

Dr. Andrew McVey, Veterinary Surgeon and Partner at MediVet Warbreck House Veterinary Centre in Liverpool, UK, added: “The PetPace collar provided us with high-resolution clinical data at the hospital, which helped stabilize the patient. More importantly, the collar monitored the patient at home, after discharge. The data, which correlated well with the owner’s subjective reports and the findings of our follow-up examinations, was instrumental in assessing the patient’s condition and making clinical decisions. This technology, never before available to veterinarians, can raise patient care and the customer relationship to a new level.”

Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian, added, “Most dogs and cats with chronic heart diseases are treated at home, often taking combinations of medications for months or years. It is challenging for clinicians to manage these cases when they rarely receive objective, quantifiable data. In traditional measurement paradigms, such data can be generated only at a veterinary facility, and not at home, where data is often more representative of the patient’s true condition. I am confident that the availability of highly-detailed, clinically-oriented data, reports and analytics will change what we know about the natural course of diseases and the most effective ways to treat them.”

THE PETPACE COLLAR IN ACTION- NON-INVASIVE, CLOSE MONITORING OF PUPPY WITH CONGENITAL VASCULAR DISEASE

Patient Condition and History

Kira, a five-month-old female Husky puppy weighing 10 pounds, was presented to the Herzliya Veterinary Hospital in Israel owing to repeated regurgitations and weight loss. Following an extensive work-up she was diagnosed with a rare congenital vascular anomaly called PRAA.

PRAA, short for Persistent Right Aortic Arch, is a congenital anomaly involving the large blood vessels around the heart. The anatomically abnormal structures cause constriction of the esophagus and prevent solid food from passing into the stomach. Typical symptoms appear when the puppy is very young and begins to eat solid food, and include frequent regurgitation, failure to thrive, stunted growth, voracious appetite and occasionally signs of pneumonia from food aspiration (lethargy, fever, coughing, difficulty breathing). PRAA requires corrective surgery to remove the constriction from the esophagus and to allow normal feeding.

In addition to PRAA, Kira was found to have aspiration pneumonia and hypoalbuminemia (low level of proteins in the blood). She was hospitalized in the ICU for intensive care and monitoring and to stabilize her condition before the surgery. Surgery turned out to be more complicated than usual, as the narrowed part of her esophagus did not release after the removal of the constriction and had to be resected. Finally, a stomach tube was placed to bypass the esophagus during the recovery period.

PetPace collar was placed on Kira towards the end of the surgery to help monitor her closely during the difficult recovery period.

Monitoring Data

During surgery, Kira’s vitals were monitored using a medical anesthesia monitor. As can be seen in the chart below, the pulse readings of the PetPace collar closely match the readings from the medical monitor.

*COMPARISON OF PULSE READINGS MADE BY AN ANESTHESIA MONITOR (PURPLE DOTS) AND THE
PETPACE SMART COLLAR (BROWN DOTS) DURING SURGERY.

The temperature chart during surgery documented the hypothermia (low body temperature) Kira experienced, as expected in a prolonged surgery in which the chest cavity is open.

*THE TEMPERATURE CHART DURING SURGERY , WHICH SHOWS HOW THE PETPACE COLLAR DOCUMENTED HYPOTHERMIA (LOW BODY TEMPERATURE) KIRA EXPERIENCED, AS EXPECTED IN A PROLONGED SURGERY
IN WHICH THE CHEST CAVITY IS OPEN.

In the following days, vital signs charts from PetPace were displayed in real time on a monitor placed in a central location in the hospital, and were continuously used to assist with the close supervision that Kira required. Kira’s vitals were mostly within normal limits.

*AGGREGATED PULSE DATA DURING POST-OP DAYS WHICH WAS NON-INVASIVELY RECORDED BY THE PETPACE SMART COLLAR

*AGGREGATED PULSE DATA DURING POST-OP DAYS WHICH WAS NON-INVASIVELY COLLECTED BY THE PETPACE SMART COLLAR

*AGGREGATED TEMPERATURE DATA DURING POST-OP DAYS WHICH WAS NON-INVASIVELY RECORDED BY THE PETPACE SMART COLLAR

Kira’s Heart Rate Variability (HRV) showed a 14% improvement following surgery, which was likely secondary to the overall improvement in her condition and the absence of significant pain.

Table

Description automatically generated

*HEART RATE VARIABILITY (HRV) DATA DURING POST-OP DAYS WHICH WAS NON-INVASIVELY RECORDED BY THE PETPACE WEARABLE TECHNOLOGY

Discussion

Intensive medical monitoring of sick or critical patients is often performed in veterinary hospitals, and requires substantial time and resources. Kira was monitored very closely because of her condition and the difficult nature of her surgery. The PetPace collar was added to Kira’s monitoring protocol to augment direct patient assessment by caregivers, enabling them to fill in data gaps between manual measurements. Having access to large amounts of data enhances the accuracy of clinical assessment. Moreover, since PetPace data is obtained automatically, without human intervention, it better reflects the patient’s true condition.

Conclusions

Using the PetPace collar for non-invasive yet intensive medical monitoring has two primary benefits. First, it provides real-time streaming health data on the patient, helping caregivers continuously assess the clinical condition. Second, it reduces the handling and stress associated with frequent manual measurements.

Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian, noted, “Using the PetPace collar for in-house intensive patient monitoring improves medical care while avoiding the increase in resources that would otherwise be required for frequent manual measurements.”

Dr. Shahar Baruch, owner of Herzliya Veterinary Hospital, Israel, and Kira’s veterinarian added, “We routinely use PetPace collars on our hospitalized pets and project the data in real time on a large screen in a central location in our hospital. Medical staff can thus maintain a higher level of vigilance without either increasing their workload or subjecting patients to excessive handling.”

The Petpace Collar in Action- Early detection of hyperthyroidism in cat

Patient Condition and History

Mya, a 14-year-old spayed female weighing 13lb, is an indoor-only, domestic shorthair cat who had no known medical problems. Carol Pipher, Mya’s owner and a veterinary technician from Southern Tier Veterinary Associates animal hospital in Vestal, NY, placed a PetPace collar on her for routine screening.

Monitoring Data and Medical Exam

The PetPace collar provided values that raised Carol’s concern, including elevated pulse levels (average – 182; Max – 231; Min – 130) and low HRV (VVTI – 8.2), so she decided to bring Mya to the hospital for a check-up.

Mya’s physical exam was unremarkable but her bloodwork showed marked elevation of thyroid hormone (T4-12.4; normal range 0.8-4.7), and an elevated Red Blood Cell count (RBC-11.6; normal range 7.12-11.4). Both changes are routinely seen in hyperthyroid cats. No other symptoms or problems were detected.

Mya was started on a course of oral medications, which effectively reduced her excess thyroid hormone levels. A 24-hour follow-up with the PetPace collar three months later showed significant improvements in all parameters. Pulse indexes were approximately 20% lower (average – 141; Max – 208; Min – 103) and HRV increased 13% (VVTI – 9.3).

ELEVATED PULSE INDEXES IN A CAT WITH OCCULT HYPERTHYROIDISM.

SIGNIFICANT DECREASES IN PULSE INDEXES FOLLOWING MEDICAL TREATMENT FOR HYPERTHYROIDISM.

Discussion

Hyperthyroidism is a hormonal disorder caused by excess production of thyroid hormones by the thyroid gland, which is located in the neck. It is a relatively common disease in older cats. Since thyroid hormones regulate metabolism and a wide variety of processes in the body, almost any organ can be affected and clinical signs vary. The disease is insidiously progressive, and is often detected and diagnosed only after serious alterations occur, such as weight loss and damage to internal organs. This makes the disease highly detrimental to health and well-being, and makes treatment complex and expensive.

In Mya’s case, data from the PetPace collar prompted a veterinary exam, which resulted in an early diagnosis, effective treatment and a good outcome. Since diagnosis was made before advanced complications had developed, Mya’s condition was not bad and she responded well to medical treatment without further issues. The PetPace smart collar was instrumental in making the diagnosis and documenting her response to treatment.

Conclusions

The PetPace collar can provide early indications of changes in individual health status and alert pet owners. This enables owners to consult their veterinarian to determine the root of the problem and provide timely relief before major complications develop.

Many chronic diseases, including hyperthyroidism, progress slowly and insidiously over time. Symptoms are typically detected relatively late in the course of the disease, even by the most dedicated and astute owners. Early detection of chronic diseases is facilitated by non-specific changes in trends data and the analytics provided by PetPace.

Dr. Cari Bowlin, Medical Director at Southern Tier Veterinary Associates noted: The data provided by the PetPace collar was what prompted us to thoroughly examine a presumably healthy cat. It enabled a timely diagnosis of a serious disease and turned my staff into believers in this innovative technology.

Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian, added, The PetPace collar enables clinics to run routine periodic screening of their clients, for example as part of an annual work-up. This can be invaluable in early detection of chronic diseases and – as exemplified in this case – can dramatically improve pet health.”

QUANTIFYING ACTIVITY AND CALORIC NEEDS

Patient Condition and History

Dottie, a 16lb, five-year-old spayed female Boston Terrier, was boarding at VetCare Harris Animal Hospital in Tampa, Florida. Her caregivers at the hospital noticed a gradual weight loss during her stay, despite her good health.

To examine the possibility that her weight loss was due to a caloric expenditure that exceeded caloric intake, Dottie was fitted with a PetPace smart collar to better quantify her activity levels and caloric expenditure.

Monitoring Data

Upon admission for boarding at VetCare Harris Animal Hospital, Dottie’s weight was 16.2lb. However, within a week her weight was down to 14.1lb. Dottie had no known medical problems, ate well twice daily, and was an extremely active dog.

Dottie’s daily activity chart showed frequent, high bursts of activity while boarding, even during the night hours, when the hospital was closed. This specific information was very helpful, since caregivers could not otherwise know about her activity patterns during the night hours.

An example of a daily activity chart during boarding, showing high activity levels

*An example of a daily activity chart during boarding, showing high activity levels

*AN EXAMPLE OF A DAILY ACTIVITY CHART DURING BOARDING, SHOWING HIGH ACTIVITY LEVELS

Dottie's activity trend chart during boarding

*Dottie’s activity trend chart during boarding, showing sustained high activity level (except for one day during which the collar was worn for only a few hours)

*DOTTIE’S ACTIVITY TREND CHART DURING BOARDING, SHOWING SUSTAINED HIGH ACTIVITY LEVEL (EXCEPT FOR ONE DAY DURING WHICH THE COLLAR WAS WORN FOR ONLY A FEW HOURS)

The PetPace collar also measured the intensity of Dottie’s activity, in addition to the amount of time spent active. The chart below shows the relative amount of time spent in each activity level for the time period examined.

Dottie's accumulated activity data divided into intensity levels.

*Dottie’s accumulated activity data divided into intensity levels. The values represent the relative amount of time spent in each activity level.

*DOTTIE’S ACCUMULATED ACTIVITY DATA DIVIDED INTO INTENSITY LEVELS. THE VALUES REPRESENT THE RELATIVE AMOUNT OF TIME SPENT IN EACH ACTIVITY LEVEL.

Dottie’s PetPace collar was equipped with a new feature that provides an Overall Activity Score – allowing easy comparison to previous time periods, and also benchmarking against other pets and across breeds. The score is based on a proprietary scale representing the combined calculated values of activity intensities, activity frequency and duration. Dottie’s overall activity score for the time she was boarding was 17.2 – one of the highest ever documented by PetPace. The typical overall activity score of healthy active dogs is around 11.

All Dottie’s other monitored and calculated parameters were stable and within normal limits, including pulse rate indices, respiratory rates indices, and HRV (Heart Rate Variability).

Daily Average Pulse
Daily Average Respiration
VVTI

*Sample of data trends graphs showing normal and stable values for a hyperactive boarder dog with weight loss.

Another, still experimental, parameter measured by PetPace is VVTI (Vaso-Vagal Tonus Index) vs. pulse rate plot. Potentially a general marker of health and well-being, this metric was also normal for Dottie.

VVTI

*VVTI (HRV INDEX) VS. PULSE SHOWING NORMAL DISTRIBUTION, LIKELY INDICATING GOOD HEALTH STATUS.

PetPace also provides an estimate of caloric expenditure based on the patient signalment (age, weight, neuter status, etc.) and activity data. This information helps pet owners and caregivers set and track activity goals and feeding regimens.

Calories Burned Chart

*CALORIC EXPENDITURE ESTIMATE FOR AN ACTIVE BOARDING DOG.

Following these findings, caregivers at the hospital increased Dottie’s food ration and she started gaining weight.

Discussion

Weight control is closely associated with activity levels and patterns. Quantifying activity and analyzing various parameters, including intensity, duration, frequency and consistency, can provide actionable insights to pet owners and medical staff who are attempting to help their pets gain, lose or maintain their weight.

Pets who are very active, like working dogs or very playful dogs, may need increased food intake to meet their needs. Quantifying activity information together with caloric expenditure helps make this process more accurate, visible, and easily sharable with relevant individuals.

Moreover, activity analytical data plays a role in overall health assessment of dogs and cats. The ability to see the activity data in the context of other physiological indicators is a unique feature of the PetPace collar, separating it from all other dog activity trackers. In this case, the fact that all other parameters and indicators were normal and consistent helped the medical staff determine that the weight loss was caused by high activity levels and insufficient caloric intake.

Conclusions

Detailed analysis of activity data is helpful in controlling weight of dogs and also in overall health assessment. Activity data should be interpreted in the context of other health indicators and medical condition.

Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian, noted, Activity data analytics are instrumental for weight control programs by making the process more accurate, objective and data-driven. However, this data has implications that reach far beyond trendy exercise tracking devices. Changes in activity or in weight may be associated with medical conditions and should be interpreted in the context of the health status of the pet.

Dottie’s veterinarian, Dr. Brian Shaw from Tampa, FL, the owner of VetCare Harris Animal Hospital added, Using PetPace collars in the hospital helps us evaluate our patients’ needs and wellbeing. It is one thing to see a hyperactive dog bouncing around, but being able to see objective, accurate data provides us with a more solid ground for clinical decisions, including caloric intake determination.

PETPACE EXAMINES THE POSSIBILITY THAT CAT’S WEIGHT LOSS WAS DUE TO A CALORIC EXPENDITURE

Patient Condition and History

To examine the possibility that her weight loss was due to a caloric expenditure that exceeded caloric intake, Dottie was fitted with a PetPace smart collar to better quantify her activity levels and caloric expenditure.

Dottie, a 16lb, five-year-old spayed female Boston Terrier, was boarding at VetCare Harris Animal Hospital in Tampa, Florida. Her caregivers at the hospital noticed a gradual weight loss during her stay, despite her good health.

Monitoring Data

Upon admission for boarding at VetCare Harris Animal Hospital, Dottie’s weight was 16.2lb. However, within a week her weight was down to 14.1lb. Dottie had no known medical problems, ate well twice daily, and was an extremely active dog.

Dottie’s daily activity chart showed frequent, high bursts of activity while boarding, even during the night hours, when the hospital was closed. This specific information was very helpful, since caregivers could not otherwise know about her activity patterns during the night hours.

*An example of a daily activity chart during boarding, showing high activity levels

*AN EXAMPLE OF A DAILY ACTIVITY CHART DURING BOARDING, SHOWING HIGH ACTIVITY LEVELS

*Dottie’s activity trend chart during boarding, showing sustained high activity level (except for one day during which the collar was worn for only a few hours)

*DOTTIE’S ACTIVITY TREND CHART DURING BOARDING, SHOWING SUSTAINED HIGH ACTIVITY LEVEL (EXCEPT FOR ONE DAY DURING WHICH THE COLLAR WAS WORN FOR ONLY A FEW HOURS)

The PetPace collar also measured the intensity of Dottie’s activity, in addition to the amount of time spent active. The chart below shows the relative amount of time spent in each activity level for the time period examined.

*Dottie’s accumulated activity data divided into intensity levels. The values represent the relative amount of time spent in each activity level.

*DOTTIE’S ACCUMULATED ACTIVITY DATA DIVIDED INTO INTENSITY LEVELS. THE VALUES REPRESENT THE RELATIVE AMOUNT OF TIME SPENT IN EACH ACTIVITY LEVEL.

Dottie’s PetPace collar was equipped with a new feature that provides an Overall Activity Score – allowing easy comparison to previous time periods, and also benchmarking against other pets and across breeds. The score is based on a proprietary scale representing the combined calculated values of activity intensities, activity frequency and duration. Dottie’s overall activity score for the time she was boarding was 17.2 – one of the highest ever documented by PetPace. The typical overall activity score of healthy active dogs is around 11.

All Dottie’s other monitored and calculated parameters were stable and within normal limits, including pulse rate indices, respiratory rates indices, and HRV (Heart Rate Variability).

PetPace Canine Weight Loss Case Study Average Pulse

PetPace Canine Weight Loss Case Study Average Respiration

PetPace Canine Weight Loss VVTI

*Sample of data trends graphs showing normal and stable values for a hyperactive boarder dog with weight loss.

Another, still experimental, parameter measured by PetPace is VVTI (Vaso-Vagal Tonus Index) vs. pulse rate plot. Potentially a general marker of health and well-being, this metric was also normal for Dottie.

VVTI (HRV Index) vs. Pulse showing normal distribution, likely indicating good health status

*VVTI (HRV INDEX) VS. PULSE SHOWING NORMAL DISTRIBUTION, LIKELY INDICATING GOOD HEALTH STATUS.

PetPace also provides an estimate of caloric expenditure based on the patient signalment (age, weight, neuter status, etc.) and activity data. This information helps pet owners and caregivers set and track activity goals and feeding regimens.

Caloric expenditure estimate for an active boarding dog

*CALORIC EXPENDITURE ESTIMATE FOR AN ACTIVE BOARDING DOG.

Following these findings, caregivers at the hospital increased Dottie’s food ration and she started gaining weight.

Discussion

Weight control is closely associated with activity levels and patterns. Quantifying activity and analyzing various parameters, including intensity, duration, frequency and consistency, can provide actionable insights to pet owners and medical staff who are attempting to help their pets gain, lose or maintain their weight.

Pets who are very active, like working dogs or very playful dogs, may need increased food intake to meet their needs. Quantifying activity information together with caloric expenditure helps make this process more accurate, visible, and easily sharable with relevant individuals.

 Moreover, activity analytical data plays a role in overall health assessment of dogs and cats. The ability to see the activity data in the context of other physiological indicators is a unique feature of the PetPace collar, separating it from all other dog activity trackers. In this case, the fact that all other parameters and indicators were normal and consistent helped the medical staff determine that the weight loss was caused by high activity levels and insufficient caloric intake.

Conclusions

Detailed analysis of activity data is helpful in controlling the weight of cats and dogs and also in overall health assessment. Activity data should be interpreted in the context of other health indicators and medical condition.

Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian, noted, Activity data analytics are instrumental for weight control programs by making the process more accurate, objective and data-driven. However, this data has implications that reach far beyond trendy exercise tracking devices. Changes in activity or in weight may be associated with medical conditions and should be interpreted in the context of the health status of the pet.”

Dottie’s veterinarian, Dr. Brian Shaw from Tampa, FL, the owner of VetCare Harris Animal Hospital added, Using PetPace collars in the hospital helps us evaluate our patients’ needs and wellbeing. It is one thing to see a hyperactive dog bouncing around, but being able to see objective, accurate data provides us with a more solid ground for clinical decisions, including caloric intake determination.”

DETECTING AND LONG-TERM MONITORING OF CHRONIC PAIN ASSOCIATED WITH HIP DYSPLASIA

Patient Condition and History

Pippa, a nine-year-old, 61lb spayed female Labrador Retriever has suffered from Hip Dysplasia from a young age.

Hip Dysplasia is a common disease affecting mostly large breed dogs, but also smaller breed dogs and cats. It involves a malformation of the hip joint that causes laxity and subsequent degeneration and inflammation. Dogs suffering from Hip Dysplasia may experience chronic pain and require treatment.

A PetPace collar was placed on Pippa to assess her overall condition and well-being in light of her Hip Dysplasia.

Monitoring Data

Statistical analysis of Pippa’s data, available through the PetPace Health Report, provided insights into Pippa’s condition. PetPace compared Pippa’s values to average values for dogs of similar breed, age, weight, and gender, and found:

• Pulse – Pippa’s overall pulse values (average 74; range 51-123) were slightly better than those typically seen in female Labrador retrievers of her age and weight (average 79; range 49-108).

• Respiration – Her respiratory values (average 17; range 10-26) were similar to the values of the reference group (average 20; range 9-29).

• Resting – Pippa spent 90.8% of the time resting, which is lower than the overall species average (81%) but similar to other Labradors of her age and weight (92%).

• Positions – While most dogs like Pippa spend approximately 13% of their rest time lying on the left side, Pippa laid only 8% of the time on that side. This finding may suggest  discomfort associated with lying on the left side, such as pain from hip dysplasia.

• HRV – all Heart Rate Variability indices, which are a potential objective markers for pain, were normal (e.g. VVTI average 11.5)

All Pippa’s values, with the exception of HRV, showed little day-to-day variation. It is interesting to note that HRV on occasion decreased to lower levels, possibly indicating intermittent pain or discomfort.

VVTI

*PIPPA’S VVTI VS. PULSE CHART SHOWING ABNORMALLY HIGH AMOUNT OF POINTS BELOW THE NORMAL RANGE (RED POINTS).

To further investigate the possibility of intermittent pain, Pippa’s caregivers employed an additional analytical tool to examine minute-to-minute HRV. To create this chart, an HRV index called VVTI (Vaso-Vagal Tonus Index) is plotted against the corresponding pulse data recorded at the same time. Preliminary data shows a statistical correlation between excessive numbers of plot points below the normal range (red dots) and various medical conditions. Pippa’s chart showed that 3.2%, a higher than normal percentage of data points (red points), fall below the normal range.

Discussion

While Pippa did not show overt signs of pain, the values recorded by the PetPace collar indicated mild and intermittent pain. Her vital signs were normal or even slightly better compared to other dogs of the same breed, age and weight. However, the position data and the HRV analysis revealed an underlying problem.

Pippa’s overall average HRV was normal, but a close look at detailed HRV data, revealed that she has ups and downs,” which can indicate intermittent pain episodes which are common for pets with inflammatory joint diseases. Various internal and external factors, such as weather, exercise, diet, and more may exacerbate the background inflammatory condition, bringing about periods of pain.

The positions data also hint at possible chronic intermittent pain. Pippa adopted a behavior pattern that includes decreased amount of time spent lying on the left side, which could be associated with increased pain or discomfort specifically on that side.

The HRV and positions data are not specific for pain secondary to hip dysplasia. They are statistical parameters indicating that a problem likely exists. However, Pippa’s owner Dr. Nitzan Kroter, a

veterinary surgeon from Enfield, UK, believes that no other medical conditions are present and therefore the data indicates chronic, intermittent pain from her hip dysplasia.

Detecting chronic pain, especially if it is intermittent in nature, is a challenge in veterinary medicine. Pets learn to compensate and do not readily show signs of pain. They may continue to eat and sleep well, appear happy and content and even be moderately active,” said Dr. Asaf Dagan, DVM, Diplomate ABVP (Canine and Feline practice), and PetPace’s Chief Veterinarian. The long term data analysis and comparisons provided by the PetPace collar can help reveal these common pain conditions, that owners may not be aware of,” he added.

Pippa is a happy dog despite her medical condition,” said Dr. Nitzan Kroter, a senior partner in Medi-Vet, UK, and Pippa’s owner. The collar’s data help me detect those intermittent pain episodes and treat them accordingly,” he continued.

Conclusions

Detecting chronic pain in animals is challenging because pets tend to hide their symptoms and compensate for their discomfort. Nonetheless, it is important to treat the pain for both humane and medical reasons. Pain has significant effect on the wellbeing of the pet and may also have negative influence on its health. Despite this, surveys repeatedly show that pain is under-diagnosed in the pet population.

The PetPace collar helps detect chronic pain by monitoring physiological and behavioral parameters associated with pain assessment. PetPace uses both real-time and long-term analytical tools to detect data values that deviate from the specific values typical for that pet. Such deviations can indicate acute exacerbations of an existing painful condition. Finally, comparisons to pets with similar attributes, such as breed, gender, age and weight, provide additional insights into the pet’s condition and wellbeing.

Hip Dysplasia, and similar joint diseases that are associated with chronic pain and inflammation, are very common in dogs and cats. Using the PetPace collar long-term on these pets can help caregivers detect chronic and intermittent pain, guiding treatment for pain relief and improving overall quality of life.

This is the title of a case study by PetPace

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum

This is the title of a case study by PetPace

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborumLorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum